4/19/2024 0 Comments Bun normal range atiA value that isn't in the normal range may still be normal for you. Your doctor will also look at your results based on your age, health, and other factors. Your lab report should show the range that your lab uses for each test. A BUN-to-creatinine ratio can help your doctor check for problems, such as dehydration, that may cause abnormal BUN and creatinine levels.Įach lab has a different range for what's normal. Blood urea nitrogen (BUN) and creatinine tests can be used together to find the BUN-to-creatinine ratio (BUN:creatinine). The level of creatinine in your blood also tells how well your kidneys are working-a high creatinine level may mean your kidneys are not working properly. Blood urea nitrogen to creatinine ratio (BUN:creatinine)Ī BUN test may be done with a blood creatinine test. A low BUN level can occur normally in the second or third trimester of pregnancy. Liver disease or damage can lower your BUN level. Heart failure, dehydration, or a diet high in protein can also make your BUN level higher. If your kidneys are not able to remove urea from the blood normally, your BUN level rises. Urea is made in the liver and passed out of your body in the urine.Ī BUN test is done to see how well your kidneys are working. Urea is made when protein is broken down in your body. In particular, prerenal disease should not be excluded by a normal ratio since diminished urea production (due to decreased protein intake or underlying liver disease) can prevent the expected rise in BUN due to increased tubular reabsorption.A blood urea nitrogen (BUN) test measures the amount of nitrogen in your blood that comes from the waste product urea. In contrast to the potential utility of a high BUN/serum creatinine ratio, a normal ratio is of limited diagnostic utility. However, this problem is chronic and cannot explain an acute rise in the BUN out of proportion to any change in the serum creatinine concentration. The BUN/serum creatinine ratio can exceed 20:1 when loss of muscle mass in a chronically ill or older patient lowers creatinine production and, therefore, the serum creatinine concentration, independent of the GFR. The BUN will rise out of proportion to the serum creatinine when urea production is increased due to GI bleed (upper somewhat more than lower), tissue breakdown, or glucocorticoid therapy. Thus, a high ratio is suggestive of prerenal disease as long as some other cause of a high ratio is not present. The BUN/Cr ratio is normal at 10 to 15:1 in ATN (intrarenal), but is often greater than 20:1 in prerenal disease due to the increase in the passive reabsorption of urea that follows the enhanced proximal reabsorption of sodium and water. *** A BUN/Cr ratio that is high when BUN and Creatinine are either low or at the lower range of normal is not going to be clinically significant. In ATN, the reabsorption of BUN or secretion of Cr is decreased making the ratio to be normal. As they pass through the renal tubule, BUN is reabsorbed from the PCT (proximal convoluted tubule) while Creatinine is not reabsorbed but instead, more is secreted into the tube in the DCT. In normal circumstances, Both BUN and Cr are filtered. Renal damage causes reduced reabsorption of BUN, therefore lowering the BUN:Cr ratio. Some sources say the normal range is 10-15:1. Dehydration or hypoperfusion is suspected. BUN is disproportionately elevated relative to creatinine in serum. Urea is made in the liver as a by-product of protein metabolism. *Note that BUN=Blood urea nitrogen which is essentially a measurement of urea. The ratio may be decreased with liver disease (due to a decrease in the formation of urea) and malnutrition. It may also be seen with increased protein, from BI bleed, or increased protein in the diet. An increased ratio may be due to a condition that causes a decrease in the flow of blood to the kidneys, such as CHF or dehydration. The ratio of BUN to creatinine is usually between 10:1 and 20:1. We may look at the BUN / Creatinine ratio to help determine the cause of renal failure.
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